Affiliation:
1. College of Biomedical Engineering Sichuan University Chengdu 610065 China
2. Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China
3. Key Laboratory of Cryogenics Science and Technology Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China
4. Department of Interventional Radiology The First Hospital of China Medical University Shenyang 110001 China
Abstract
AbstractMicrowave thermal therapy (MWTT) is a novel clinical treatment of tumors via inducing thermal effect and anti‐tumor immune response, exhibiting advantages of deep penetration, minimal invasion, and high heat conversion efficiency. However, effective ablation is difficult to cover the entire tumor area, and heat‐shock protein 90 (HSP90) is often upregulated after ablation to generate heat tolerance of sublethal tumors and weaken the induced antitumor immune effect, resulting in a high rate of tumor recurrence and metastasis. Herein, a multifunctional nanoregulator of metal phenolic network‐coated ZnS (ZnS@Ga‐tannic acid, ZGT) is proposed to release H2S for synergically enhancing MWTT. Under the costimulation of MW radiation and acidic tumor microenvironment, ZGT can improve the MW thermal effects of tumors to promote thermal damage and release H2S to induce tumor apoptosis. The released H2S can also inhibit the production of ATP and then downregulate the expression of HSP90, strengthening the activated systemic antitumor immune response after ablation. This nanoregulator provides a new way for achieving compensation effect for MWTT. The strategy of H2S gas to downregulate HSP90 and positively regulate antitumor immune response introduces a novel direction for reducing the risk of tumor recurrence and metastasis after thermal therapy.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Beijing Municipality
China Postdoctoral Science Foundation
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials