An Aggregation‐Induced Emission Molecule‐Assembled Nanovaccine with Self‐Adjuvanted Function for Cancer Immunotherapy

Author:

Zhang Xiaoyan12,Wang Kefei3,Gao Zhiyuan2,Wu Zelin2,Liu Wei3,Li Jisen2,Gao Heqi2,Wei Jun3,Ding Dan12ORCID,Zheng Wenting3

Affiliation:

1. Tianjin Stomatological Hospital School of Medicine Nankai University Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction State Key Laboratory of Experimental Hematology Tianjin 300041 China

2. Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciences Nankai University Tianjin 300071 China

3. State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300020 China

Abstract

AbstractCancer nanovaccine is a promising therapeutic strategy; however, the complicated composition and ambiguous structure of cancer nanovaccines hinder their clinical application. Thus, developing minimalist nanovaccine with simple structural molecule and potent immunostimulatory function is with great value. Herein, an organic small molecule with well‐defined molecular structure and strong aggregation‐induced emission (AIE) activity is synthesized. This molecule can self‐assemble into nanoparticle (NM‐7) acting as not only adjuvant but also carrier to capture model antigen ovalbumin to form nanovaccine, which can effectively deliver and chronically release antigens and induce effective antigen cross‐presentation in draining lymph nodes. Additionally, the photophysical property of AIE molecule facilitates the determination of in vivo tissue distribution of NM‐7. Notably, NM‐7/ovalbumin (OVA) nanovaccine induces robust tumor‐specific CD8+ T‐cell responses with greatly reduced cell exhaustion. Accordingly, NM‐7/OVA nanovaccine shows potent efficacy in both prevention and therapeutic tumor models, and produces an impressive synergistic therapeutic effect when combined with immune checkpoint blockade (ICB) therapy. Therefore, AIE nanomaterial NM‐7 with simple synthesis, well‐defined molecular structure and self‐adjuvanted function provides a new reference and general strategy for cancer vaccine development.

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3