Peptide Drones Facilitating the Transdermal Delivery of Antitumor Proteins for Melanoma Treatment

Author:

Kim Hyunji1,Kim Suin1,Lee Guewha2,Kim Ji‐eun3,Jeong Woo‐jin14ORCID

Affiliation:

1. Department of Biological Sciences and Bioengineering Inha University Incheon 22212 Republic of Korea

2. Hu Evergreen Pharm Incheon 22204 Republic of Korea

3. Department of Chemical and Biochemical Engineering Dongguk University 30 Pildong‐ro 1‐gil, Jung‐gu Seoul 04620 Republic of Korea

4. Department of Biological Engineering Inha University Incheon 22212 Republic of Korea

Abstract

AbstractTopical treatment offers a viable alternative for melanoma patients incompatible with surgical interventions. Herein, the study develops a skin‐penetrating peptide (SPP)‐based peptide drone (PD) for the transdermal delivery of antitumor proteins. To achieve cost‐effective therapeutics, Concanavalin A (ConA), which can be prepared through an extraction method, is loaded onto PDs. Compared with free proteins, ConA‐PD complexes (CPCs) demonstrate significantly greater skin permeation. Moreover, the CPCs exhibit potent anticancer activity both in vitro and in vivo, which substantially surpass the efficacy of the Aldara (imiquimod) cream. The CPC‐treated mouse skin remains clear, whereas Aldara cream induces side effects, including psoriasis‐like skin inflammation. The antimetastatic activity of the PD is identified as another advantage of CPC. The use of ConA as an anticancer agent has been significantly limited due to its high hepatotoxicity; however, the transdermal delivery strategy minimizes its hepatic absorption and, in turn, results in negligible hepatotoxicity. These results demonstrate the potential of the CPC as a novel therapeutic agent or an adjunct to other modalities for melanoma treatment, overcoming the limitations of existing materials while exhibiting superior efficacy.

Funder

Ministry of Trade, Industry and Energy

Ministry of Science and ICT, South Korea

Publisher

Wiley

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