Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing-Reference-Cited by-同舟云学术

Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing

Published:2023-04-27 Issue:11 Volume:19 Page:5114-5128
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Mahalingam Gowsaly¹,Samtani Suraj¹,Lam Ben Chun Pan¹²,Lipnicki Darren M¹,Lima‐Costa Maria Fernanda³,Blay Sergio Luis⁴,Castro‐Costa Erico³,Shifu Xiao⁵,Guerchet Maëlenn⁶,Preux Pierre‐Marie⁶,Gbessemehlan Antoine⁶,Skoog Ingmar⁷⁸,Najar Jenna⁷⁸,Sterner Therese Rydberg⁷,Scarmeas Nikolaos⁹¹⁰,Yannakoulia Mary¹¹,Dardiotis Themis¹²,Kim Ki‐Woong¹³¹⁴¹⁵,Riedel‐Heller Steffi¹⁶,Röhr Susanne¹⁶¹⁷¹⁸,Pabst Alexander¹⁶,Shahar Suzana¹⁹,Numbers Katya¹,Ganguli Mary²⁰,Hughes Tiffany F.²¹,Chang Chung‐Chou H.²²,Crowe Michael²³,Ng Tze Pin²⁴,Gwee Xinyi²⁴,Chua Denise Qian Ling²⁴,Rymaszewska Joanna²⁵,Wolf‐Ostermann Karin²⁶,Welmer Anna‐Karin²⁷,Stafford Jean²⁸,Mélis René²⁹,Vernooij‐Dassen Myrra³⁰,Jeon Yun‐Hee³¹,Sachdev Perminder S¹,Brodaty Henry¹,

Affiliation:

1. Centre for Healthy Brain Ageing (CHeBA) Discipline of Psychiatry and Mental Health Faculty of Medicine and Health UNSW Sydney Australia

2. School of Psychology and Public Health La Trobe University Melbourne UNSW Sydney Australia

3. Center for Studies in Public Health and Aging’ René Rachou Research Center Oswaldo Cruz Foundation Belo Horizonte Minas Gerais Brazil

4. Department of Psychiatry Federal University of Sao Paulo Sao Paulo São Paulo Brazil

5. Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai Jiaotong University School of Medicine Shanghai China

6. Inserm U1094 IRD UMR270 Univ. Limoges, CHU Limoges, EpiMaCT – Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth Limoges France

7. Department of Psychiatry and Neurochemistry Neuropsychiatric Epidemiology Unit Institute of Neuroscience and Physiology the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), at the University of Gothenburg Mölndal Sweden

8. Region Västra Götaland Psychiatry Cognition and Old Age Psychiatry Clinic Sahlgrenska University Hospital Gothenburg Sweden

9. 1st Department of Neurology Aiginition Hospital, National and Kapodistrian University of Athens Athens Greece

10. Taub Institute for Research in Alzheimer's Disease and the Aging Brain The Gertrude H. Sergievsky Center Department of Neurology Columbia University New York New York USA

11. Department of Nutrition and Dietetics Harokopio University Athens Greece

12. Department of Neurology University of Thessaly Larisa Greece

13. Department of Neuropsychiatry Seoul National University Bundang Hospital Seongnam South Korea

14. Department of Psychiatry Seoul National University College of Medicine Seoul South Korea

15. Department of Brain and Cognitive Science Seoul National University College of Natural Sciences Seoul South Korea

16. Institute of Social Medicine Occupational Health and Public Health (ISAP) Faculty of Medicine University of Leipzig Leipzig Germany

17. Global Brain Health Institute Trinity College Dublin Dublin Ireland

18. Health and Ageing Research Team School of Psychology Massey University Palmerston New Zealand

19. Centre for Healthy Aging and Wellness Faculty of Health Sciences Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia

20. Departments of Psychiatry Epidemiology, and Neurology, University of Pittsburgh Pittsburgh Pennsylvania USA

21. Youngstown State University Youngstown Ohio USA

22. Department of Medicine School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA

23. Department of Psychology University of Alabama at Birmingham Birmingham Alabama USA

24. Yong Loo Lin School of Medicine Department of Psychological Medicine National University of Singapore Singapore Singapore

25. Department of Psychiatry Wroclaw Medical University Wroclaw Poland

26. Department of Health Services and Nursing Science Research Institute for Public Health and Nursing Research (IPP) University of Bremen Bremen Germany

27. Aging Research Center & Division of Physiotherapy Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden

28. MRC Unit for Lifelong Health and Ageing University College London London UK

29. Department of Geriatrics Radboud University Medical Centre Nijmegen Gelderland The Netherlands

30. Faculty of Medical Sciences Radboud University Nijmegen The Netherlands

31. Susan Wakil School of Nursing and Midwifery Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia

Abstract

AbstractIntroductionPrevious meta‐analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers.MethodsWe used individual participant data (N = 39271, Mage = 70.67 (40‐102), 58.86% female, Meducation = 8.43 years, Mfollow‐up = 3.22 years) from 13 longitudinal ageing studies. A two‐stage meta‐analysis of Cox regression models examined the association between social connection markers with our primary outcomes.ResultsWe found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.DiscussionDifferent aspects of social connections – structure, function, and quality – are associated with benefits for healthy aging internationally.Highlights

Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI.

Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia.

Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality.

Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality.

Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference50 articles.

1. How should we define health?

2. Social health and dementia: a European consensus on the operationalization of the concept and directions for research and practice

3. The Major Health Implications of Social Connection

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