<i>APOE</i> and immunity: Research highlights-Reference-Cited by-同舟云学术

APOE and immunity: Research highlights

Published:2023-03-28 Issue:6 Volume:19 Page:2677-2696
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Kloske Courtney M.¹,Barnum Christopher J.²,Batista Andre F.³⁴,Bradshaw Elizabeth M.⁵,Brickman Adam M.⁶,Bu Guojun⁷,Dennison Jessica⁸,Gearon Mary D.⁹,Goate Alison M.¹⁰,Haass Christian¹¹¹²,Heneka Michael T.¹³,Hu William T.¹⁴,Huggins Lenique K. L.¹⁵¹⁶,Jones Nahdia S.¹⁷,Koldamova Radosveta¹⁸,Lemere Cynthia A.³⁴,Liddelow Shane A.¹⁹,Marcora Edoardo²⁰,Marsh Samuel E.²¹²²²³,Nielsen Henrietta M.²⁴,Petersen Kellen K.²⁵,Petersen Melissa²⁶,Piña‐Escudero Stefanie D.²⁷,Qiu Wei Qiao²⁸,Quiroz Yakeel T.²⁹,Reiman Eric³⁰³¹,Sexton Claire¹^ORCID,Tansey Malú Gámez³²,TCW Julia³³,Teunissen Charlotte E.³⁴,Tijms Betty M.³⁵³⁶,van der Kant Rik³⁷³⁸,Wallings Rebecca³⁹,Weninger Stacie C.⁴⁰,Wharton Whitney⁴¹,Wilcock Donna M.⁴²,Wishard Tyler James⁴³,Worley Susan L⁴⁴,Zetterberg Henrik⁴⁵⁴⁶⁴⁷⁴⁸⁴⁹,Carrillo Maria C.¹

Affiliation:

1. Alzheimer's Association Chicago Illinois USA

2. INmune Bio, Inc La Jolla California USA

3. Department of Neurology Ann Romney Center for Neurologic Diseases Brigham and Women's Hospital Boston Massachusetts USA

4. Departments of Neurology Harvard Medical School Boston Massachusetts USA

5. Department of Neurology Columbia University Irving Medical Center New York New York USA

6. Taub Institute for Research on Alzheimer's Disease and the Aging Brain G.H. Sergievsky Center and Department of Neurology Vagelos College of Physicians and Surgeons Columbia University New York New York USA

7. Department of Neuroscience Mayo Clinic Jacksonville Florida USA

8. Department of Psychiatry & Behavioral Sciences University of Miami Miller School of Medicine Miami Florida USA

9. Department of Physiology University of Kentucky Lexington Kentucky USA

10. Department of Genetics & Genomic Sciences Ronald M. Loeb Center for Alzheimer's disease Icahn School of Medicine at Mount Sinai New York New York USA

11. Metabolic Biochemistry Biomedical Center (BMC) Faculty of Medicine LMU Munich Munich Germany

12. German Center for Neurodegenerative Diseases (DZNE) Munich Germany 3 Munich Cluster for Systems Neurology (SyNergy) Munich Germany

13. Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg Esch‐sur‐Alzette Luxembourg

14. Department of Neurology Rutgers‐Robert Wood Johnson Medical School and Center for Healthy Aging Rutgers Institute for Health Health Care Policy, and Aging Research New Brunswick New Jersey USA

15. Department of Biology Duke University Durham North Carolina USA

16. Yale School of Medicine New Haven Connecticut USA

17. Interdisciplinary Program in Neuroscience Georgetown University Washington District of Columbia USA

18. EOH School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA

19. Neuroscience Institute and Departments of Neuroscience & Physiology and of Ophthalmology NYU Grossman School of Medicine New York New York USA

20. Ronald M. Loeb Center for Alzheimer's disease Dept. of Genetics & Genomic Sciences Dept. of Neuroscience Icahn School of Medicine at Mount Sinai New York New York USA

21. F.M. Kirby Neurobiology Center Boston Children's Hospital Boston Massachusetts USA

22. Harvard Medical School Boston Massachusetts USA

23. Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts USA

24. Department of Biochemistry and Biophysics Stockholm University Stockholm Sweden

25. The Saul R. Korey Department of Neurology Albert Einstein College of Medicine Bronx New York USA

26. Department of Family Medicine Institute of Translational Research University of North Texas Health Science Center Fort Worth Texas USA

27. Global Brain Health Institute Department of Neurology University of California San Francisco California USA

28. Boston University School of Medicine Boston Massachusetts USA

29. Departments of Psychiatry and Neurology Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

30. Banner Alzheimer's Institute Phoenix Arizona USA

31. Banner Research Phoenix Arizona USA

32. Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease College of Medicine University of Florida Gainesville Florida USA

33. Department of Pharmacology & Experimental Therapeutics Boston University School of Medicine Boston Massachusetts USA

34. Neurochemistry Laboratory Clinical Chemistry department Amsterdam Neuroscience Program Neurodegeneration Amsterdam University Medical Centers Vrije Universiteit Amsterdam Amsterdam The Netherlands

35. Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam The Netherlands

36. Amsterdam Neuroscience Neurodegeneration Amsterdam The Netherlands

37. Department of Functional Genomics Center for Neurogenomics and Cognitive Research (CNCR) VU University Amsterdam Amsterdam The Netherlands

38. Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Amsterdam University Medical Center Amsterdam The Netherlands

39. CTRND Department of Neuroscience University of Florida Florida USA

40. FBRI Cambridge Massachusetts USA

41. School of Nursing EmoryUniversity Atlanta Georgia USA

42. Sanders‐Brown Center on Aging and Department of Physiology University of Kentucky Lexington Kentucky USA

43. Psychiatry & Biobehavioral Sciences University of California Los Angeles Los Angeles California USA

44. Independent science writer Bryn Mawr Pennsylvania USA

45. Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden

46. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

47. Department of Neurodegenerative Disease UCL Institute of Neurology Queen Square London UK

48. UK Dementia Research Institute at UCL London UK

49. Hong Kong Center for Neurodegenerative Diseases Clear Water Bay Hong Kong China

Abstract

AbstractINTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.METHODSThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.RESULTSDuring the 4‐day meeting, presenters illuminated aspects of the cross‐talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).DISCUSSIONThis manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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