Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5‐HT2A and D2 receptor interaction pathways

Author:

Islam Muhammad Torequl123ORCID,Chowdhury Raihan23,Bhuia Md. Shimul23ORCID,Chakrabarty Brototi4,Kundu Neloy1,Akbor Md. Showkot2,Sheikh Salehin23,Chowdhury Rokibul Islam23,Ansari Siddique Akber5ORCID,Ansari Irfan Aamer6,Islam Md. Amirul17ORCID

Affiliation:

1. Pharmacy Discipline Khulna University Khulna Bangladesh

2. Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh

3. Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd., Bangladesh Gopalganj Bangladesh

4. Department of Pharmaceutical Sciences, College of Pharmacy University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA

5. Department of Pharmaceutical Chemistry, College of Pharmacy King Saud University Riyadh Saudi Arabia

6. Department of Drug Science and Technology University of Turin Turin Italy

7. Department of Pharmacy East West University Dhaka Bangladesh

Abstract

AbstractSchizophrenia affects identification and disturbs our thinking and motivational capacity. Long‐term use of daidzin (DZN) is evident to enhance attention and memory in experimental animals. This study aimed to investigate the effect of DZN on Swiss mice. To check animals' attention, identification, thinking, and motivational ability, we performed behavioral studies using marble burying, dust removal, and trained swimming protocols. For this, a total of 36 male Swiss albino mice were randomly divided into six groups, consisting of 6 animals in each group, as follows: control (vehicle), DZN‐1.25, DZN‐2.5, DZN‐5 mg/kg, olanzapine (OLN)‐2, and a combination of DZN‐1.25 with OLN‐2. Additionally, in silico studies are also performed to understand the possible molecular mechanisms behind this neurological effect. Findings suggest that DZN dose‐dependently and significantly (p < .05) increased marble burying and removed dust while reducing the time to reach the target point. DZN‐1.25 was found to enhance OLN's effect significantly (p < .05), possibly via agonizing its activity in animals. In silico findings suggest that DZN has strong binding affinities of ‐10.1 and ‐10.4 kcal/mol against human serotonin 2 A (5‐HT2A) and dopamine 2 (D2) receptors, respectively. Additionally, DZN exhibits favorable pharmacokinetic and toxicity properties. We suppose that DZN may exert its attention‐ and memory‐enhancing abilities by interacting with 5‐HT2A and D2 receptors. It may exert a synergistic antischizophrenia‐like effect with the standard drug, OLN. Further studies are required to discover the exact molecular mechanism for this neurological function in animals.

Funder

King Saud University

Publisher

Wiley

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