Affiliation:
1. Department of Bioscience & Biotechnology Banasthali Vidyapith Banasthali Rajasthan India
2. Department of Pharmacy Banasthali Vidyapith Banasthali Rajasthan India
3. Department of Pharmacy, School of Chemical Sciences and Pharmacy Central University of Rajasthan Kishangarh Rajasthan India
4. Department of Internal Medicine, Division of Cardiology LSU Health Sciences Center Shreveport Louisiana USA
5. Department of Chemistry Banasthali Vidyapith Banasthali Rajasthan India
Abstract
ABSTRACTThe most prevalent and bioactive cucurbitacin is Cucurbitacin B (CuB, C32H46O8), which is a tetracyclic triterpene chiefly present in the Cucurbitaceae family. CuB has a wide spectrum of pharmacological properties namely antioxidant, anticancer, hepatoprotective, anti‐inflammatory, antiviral, hypoglycaemic, insecticidal, and neuroprotective properties, owing to its ability to regulate several signaling pathways, including the Janus kinase/signal transducer and activator of transcription‐3 (JAK/STAT3), AMP‐activated protein kinase (AMPK), nuclear factor (NF)‐κB, nuclear factor erythroid 2‐related factor‐2/antioxidant responsive element (Nrf2/ARE), phosphoinositide 3‐kinase (PI3K)/Akt, mitogen‐activated protein kinase (MAPK), Hippo‐Yes‐associated protein (YAP), focal adhesion kinase (FAK), cancerous inhibitor of protein phosphatase‐2A/protein phosphatase‐2A (CIP2A/PP2A), Wnt and Notch pathways. The present review highlights the medicinal attributes of Cucurbitacin B (CuB) with special emphasis on their signaling pathways to provide key evidence of its therapeutic utility in the near future.