Short‐term outcomes of pancreatoduodenectomy in older individuals over a 9‐year period using real‐world data: A multilevel analysis based on a nationwide administrative database in Japan

Author:

Mori Yasuhisa1ORCID,Okawara Makoto2,Shibao Kazunori1,Kohi Shiro1,Tamura Toshihisa1,Sato Norihiro1,Fujino Yoshihisa2,Fushimi Kiyohide3,Matsuda Shinya4,Hirata Keiji1

Affiliation:

1. Department of Surgery 1, School of Medicine University of Occupational and Environmental Health Kitakyushu Japan

2. Department of Environmental Epidemiology Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health Kitakyushu Japan

3. Department of Health Policy and Informatics Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Tokyo Japan

4. Department of Preventive Medicine and Community Health, School of Medicine University of Occupational and Environmental Health Kitakyushu Japan

Abstract

AbstractBackgroundWe aimed to evaluate the short‐term outcomes of pancreatoduodenectomy (PD) in older individuals.MethodsData from the Japanese Diagnosis Procedure Combination database on 62 275 patients who underwent PD from 1 April 2012 to 31 March 2020 were analyzed. Patients were divided into five age groups: <70, 70–74, 75–79, 80–84, and ≥85 years. The associations between postoperative outcomes and age were investigated using multilevel analysis. The mean differences in length of hospital stay and cost were also compared.ResultsThe rate of PD in older individuals increased annually. Compared with the youngest age group (< 70 years), the incidence rate ratios for in‐hospital mortality were 1.52 (95% confidence interval [CI]: 1.30–1.76), 2.07 (1.82–2.37), 2.29 (1.94–2.71), and 2.92 (2.20–3.87) in the 70–74, 75–79, 80–84, and ≥ 85‐year‐old age groups, respectively (all p < .001). Postoperative complications, length of postoperative hospital stay, and cost increased significantly with increasing age.ConclusionsThese real‐world data emphasize the higher levels of morbidity, mortality, and cost in older patients. Careful attention should be paid when considering the indication for PD in older individuals.

Funder

Ministry of Health, Labour and Welfare

Publisher

Wiley

Subject

Hepatology,Surgery

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