Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study-Reference-Cited by-同舟云学术

Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study

Published:2023-09-20 Issue:11 Volume:45 Page:2862-2873
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Calabrese Luca¹,Tagliabue Marta²³^ORCID,Grammatica Alberto⁴,De Berardinis Rita²^ORCID,Corso Federica⁵⁶,Gazzini Luca¹,Abousiam Monir¹,Fazio Enrico¹,Mattavelli Davide⁴^ORCID,Fontanella Walter⁷,Giannini Lorenzo⁷,Bresciani Lorenzo⁷,Bruschini Roberto²,Gandini Sara⁸,Piazza Cesare⁴^ORCID,Ansarin Mohssen²^ORCID

Affiliation:

1. Department of Otolaryngology‐Head and Neck Surgery Hospital of Bolzano (SABES‐ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU) Bolzano Italy

2. Department of Otorhinolaryngology and Head and Neck Surgery IEO, European Institute of Oncology IRCCS Milan Italy

3. Department of Biomedical Sciences University of Sassari Sassari Italy

4. Unit of Otorhinolaryngology – Head and Neck Surgery, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia, School of Medicine Brescia Italy

5. Department of Mathematics (DMAT) Politecnico di Milano Milan Italy

6. Centre for Health Data Science (CHDS), Human Techonopole Milan Italy

7. Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery Fondazione IRCCS National Cancer Institute of Milan Milan Italy

8. Department of Experimental Oncology IEO European Institute of Experimental Oncology IRCCS Milan Italy

Abstract

AbstractBackgroundA multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).MethodsWe studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.ResultsIn the CTS group, survival and prognosis were significantly associated with positive lymph‐nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T‐N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause‐Specific Survival (CSS) of 3.24 (95% CI: 1.71–6.11; p < 0.001); HR Loco‐Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47–4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01–0.77; p = 0.03).ConclusionPerforming the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27517

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