Synthesis of quinazolines over recyclable Fe3O4@SiO2‐PrNH2‐Fe3+ nanoparticles: A green, efficient, and solvent‐free protocol

Abstract

A practical and efficient method is developed for efficient synthesis of quinazoline derivatives through condensation reaction of 2‐aminoaryl ketone, an aldehyde, and ammonium acetate, over magnetic Fe3O4@SiO2‐PrNH2‐Fe3+ NPs as a recyclable nanocatalyst, under solvent‐free conditions. The as‐prepared nanocatalyst was characterized using Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Mild conditions, easy work up, high purity of the products, recyclability, readily availability, nontoxicity, economical, and environmental‐friendly nature of the iron catalyst are the attractive features of this methodology.