Narrow‐Band Imaging in Transoral Laser Surgery for Early Glottic Cancer: A Randomized Controlled Trial

Abstract

AbstractObjectiveAssessing whether the additional use of narrow‐band imaging (NBI) in transoral laser surgery (TOLS) for early laryngeal cancer improves clinical outcomes.Study DesignRandomized controlled trial, performed between September 2015 and November 2022.SettingA tertiary referral hospital in The Netherlands.MethodsTOLS was carried out in 113 patients. The procedure was performed with white light imaging (WLI, n = 56) alone, or combined with NBI (n = 57). Patients received frequent follow‐up laryngoscopy. Resection margin status, recurrence rate, and recurrence‐free survival at 12 months, 18 months, and after study termination (maximum 86 months) were analyzed.ResultsThirty‐one cases in the WLI group had a positive resection margin, versus 16 in the NBI group (p = .002). After 12 months, the recurrence‐free survival was 92%: 87% for WLI versus 96% for NBI, p = .07. The recurrence rate was 7/56 (13%) for WLI, versus 2/57 (4%) for NBI, p = .09. After 18 months, the recurrence‐free survival was 84% for WLI versus 96% for NBI, p = .02. The recurrence rate was 9/56 (16%) for WLI, versus 2/57 (4%) for NBI, p = .02. After study termination, the recurrence‐free survival was 71% for WLI versus 83% for the NBI group (p = .08). The recurrence rate was 16/56 for WLI, versus 10/57 for NBI (p = .16).ConclusionThe additional use of NBI during TOLS significantly decreased the number of positive resection margins. Although not statistically significant at all time points, patients treated with NBI‐supported TOLS showed a lower recurrence rate and better recurrence‐free survival. Further studies in larger patient groups are needed to confirm these results.