Affiliation:
1. Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China
2. China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing China
3. Department of Epidemiology and Health Statistics School of Public Health Capital Medical University Beijing China
4. Beijing Municipal Key Laboratory of Clinical Epidemiology Beijing China
5. Department of Cardiology Kailuan Hospital North China University of Science and Technology Tangshan China
6. Department of Clinical Epidemiology and Clinical Trial Capital Medical University Beijing China
Abstract
AbstractAimsTo investigate the associations of baseline and longitudinal cardiovascular health (CVH) measured by ‘Life's Essential 8’ (LE8) metrics with the risk of diabetes in Chinese people with normoglycaemia or prediabetes.Materials and MethodsA total 86,149 participants without diabetes were enroled from the Kailuan study and were stratified by baseline glycaemic status (normoglycaemia or prediabetes). Cardiovascular health score ranged from 0 to 100 points was categorised into low (0–49), middle (50–79), and high (80–100) CVH status. Cox regressions were used to assess the associations of baseline and time‐updated CVH status with incident diabetes in the overall cohort and across baseline glycaemic statuses.ResultsDuring a median follow‐up of 12.94 (interquartile rage: 12.48–13.16) years, we identified 13,097 (15.20%) cases of incident diabetes. Baseline and time‐updated high CVH status was associated with a lower risk of diabetes, the corresponding hazard ratio (HR) versus low CVH status was 0.27 (95% confidence interval [CI], 0.23–0.31) and 0.26 (95% CI, 0.23–0.30) in the overall cohort, respectively. Additionally, the effect of high CVH on diabetes was more prominent in participants with normoglycaemia than those with prediabetes (P < 0.0001), with an HR of 0.26 (95% CI, 0.22–0.31) versus 0.50 (95% CI, 0.41–0.62) for baseline CVH, and 0.25 (95% CI, 0.21–0.30) versus 0.39 (95% CI, 0.32–0.48) for time‐updated CVH.ConclusionsElevated baseline and longitudinal CVH score assessed by LE8 metrics is associated with a lower risk of subsequent diabetes, especially in normoglycaemic adults.
Funder
National Key Research and Development Program of China
Capital Medical University
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine