Affiliation:
1. Department of Chemistry IISER Bhopal Bhopal Bypass Road Bhauri, Bhopal, MP 462066 India
2. Department of Chemical Sciences IISER Kolkata Mohanpur, Haringhata, WB 741246 India
Abstract
AbstractNatural product synthesis has been the prime focus for the development of new chemical transformations and the drug discovery. The dimeric and oligomeric hexahydropyrrolo[2,3‐b]indole alkaloids represent a architecturally intriguing class of cyclotryptamine alkaloids. These alkaloids share contiguous stereogenic centers with vicinal all‐carbon quaternary stereogenic centers. Members of this class of alkaloids are reported to show interesting biological activities. Therefore, there are tremendous synthetic interests not only because of their striking architecture but also due to their important biological activities. In this feature article we have discussed the detailed biogenetic hypothesis of these alkaloids and various elegant strategies from different groups, including our contributions in this area. Special emphasis is given for the synthetic approaches to dimeric, trimeric and tetrameric hexahydropyrrolo[2,3‐b]indole alkaloids.
Funder
Science and Engineering Research Board