Affiliation:
1. Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology 130 Meilong Road 200237 Shanghai P. R. China
Abstract
AbstractA metal‐free and oxidant‐free electrochemically enabled strategy for C‐3 formylation of imidazopyridines using trimethylamine as a one‐carbon source has been established. This conversion has high functional group compatibility under mild conditions and ensures late‐stage functionalization of pharmaceutical molecules. Furthermore, unexpected hexafluoroisopropoxylation products have been observed in some cases. Mechanistic studies using cyclic voltammetry and control experiments reveal the key intermediate of the formylation process.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
General Chemistry,Biochemistry,Organic Chemistry
Cited by
3 articles.
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