pH‐Sensitive Glucose‐Powered Nanomotors for Enhanced Intracellular Drug Delivery and Ferroptosis Efficiency

Author:

Ji Yuxing1ORCID,Pan Yanan1,Ma Xuemei1,Ma Yan1,Zhao Zhongxiang1,He Qiang2ORCID

Affiliation:

1. School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine Guangzhou 510006 China

2. School of Medicine and Health Harbin Institute of Technology Harbin 150001 China

Abstract

AbstractWe propose a glucose‐powered Janus nanomotor where two faces are functionalized with glucose oxidase (GOx) and polydopamine‐Fe3+ chelates (PDF), respectively. In the glucose fuel solution, the GOx on the one side of these Janus nanomotors catalytically decomposes glucose fuels into gluconic acid and hydrogen peroxide (H2O2) to drive them at a speed of 2.67 μm/s. The underlying propulsion mechanism is the glucose‐based self‐diffusiophoresis owing to the generated local glucose concentration gradient by the enzymatic reaction. Based on the enhanced diffusion motion, such nanomotors with catalytic activity increase the uptake towards cells and subsequently exhibit excellent capabilities for Fe3+ ions delivery and H2O2 generation for enhancing ferroptosis efficiency for inducing cancer cell death. In particular, the Fe3+ ions are released from nanomotors in a slightly acidic environment, and subsequently generate toxic hydroxyl radicals via Fenton reactions, which accumulation reactive oxygen species (ROS) level (~300 %) and further lipid peroxidation (LPO) strengthened ferroptosis therapy for cancer treatment. The as‐developed glucose‐powered Janus nanomotor with efficient diffusion and Fe ions delivery capabilities show great promise as a potential in biomedical applications.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Biochemistry,Organic Chemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. pH-responsive glucose-powered Janus polymer brushes nanomotors for drug delivery and controlled release;Colloids and Surfaces A: Physicochemical and Engineering Aspects;2024-03

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