Contemporary Considerations for Constructing a Genetic Risk Score: An Empirical Approach

Author:

Goldstein Benjamin A.1,Yang Lingyao2,Salfati Elias3,Assimes Themistoclies L.3

Affiliation:

1. Department of Biostatistics and Bioinformatics; Duke University; Durham North Carolina United States of America

2. Quantitative Sciences Unit; Stanford School of Medicine; Palo Alto California United States of America

3. Division of Cardiovascular Medicine; Stanford School of Medicine; Palo Alto California United States of America

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Wiley

Subject

Genetics(clinical),Epidemiology

Reference37 articles.

1. Genetic scoring analysis: a way forward in genome wide association studies?;Amin;Eur J Epidemiol,2009

2. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J R Stat Soc Ser B,1995

3. Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies;Chatterjee;Nat. Genet.,2013

4. Use and misuse of the receiver operating characteristic curve in risk prediction;Cook;Circulation,2007

5. Assessing calibration of prognostic risk scores;Crowson;Stat Methods Med Res,2014

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