Genome‐wide Association Study and Meta‐analysis on Alcohol‐Associated Liver Cirrhosis Identifies Genetic Risk Factors

Author:

Schwantes‐An Tae‐Hwi1ORCID,Darlay Rebecca2,Mathurin Philippe3,Masson Steven4,Liangpunsakul Suthat5,Mueller Sebastian6,Aithal Guruprasad P.7,Eyer Florian8ORCID,Gleeson Dermot9,Thompson Andrew10,Muellhaupt Beat11,Stickel Felix11,Soyka Michael1213,Goldman David14,Liang Tiebing5,Lumeng Lawrence5,Pirmohamed Munir10,Nalpas Bertrand1516,Jacquet Jean‐Marc15,Moirand Romain17,Nahon Pierre181920ORCID,Naveau Sylvie21,Perney Pascal22,Botwin Greg2324,Haber Paul S.2526,Seitz Helmut K.6,Day Christopher P.4,Foroud Tatiana M.1,Daly Ann K.4,Cordell Heather J.2,Whitfield John B.27ORCID,Morgan Timothy R.23ORCID,Seth Devanshi252628ORCID,

Affiliation:

1. Department of Medical and Molecular Genetics Indiana University Indianapolis IN

2. Population Health Sciences Institute Faculty of Medical Sciences Newcastle UniversityInternational Centre for Life Central Parkway, Newcastle upon Tyne United Kingdom

3. CHRU de LilleHôpital Claude Huriez Lille Cedex France

4. Faculty of Medical Sciences Newcastle University Medical SchoolFramlington Place Newcastle upon Tyne United Kingdom

5. Division of Gastroenterology and Hepatology Department of Medicine Indiana University Indianapolis IN

6. Department of Internal Medicine Salem Medical Center and Center for Alcohol Research University of Heidelberg Heidelberg Germany

7. NIHR Nottingham Biomedical Research CentreNottingham University Hospitals and the University of Nottingham Nottingham United Kingdom

8. Division of Clinical Toxicology Department of Internal Medicine 2 Klinikum Rechts der Isar School of Medicine Technical University of Munich Munich Germany

9. The Clinical Research Facility The Royal Hallamshire Hospital Sheffield United Kingdom

10. MRC Centre for Drug Safety ScienceLiverpool Centre for Alcohol ResearchUniversity of LiverpoolThe Royal Liverpool and Broadgreen University Hospitals NHS Trust, and Liverpool Health Partners Liverpool United Kingdom

11. Department of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland

12. Psychiatric Hospital University of Munich Munich Germany

13. Privatklinik Meiringen Willigen Meiringen Switzerland

14. Laboratory of Neurogenetics NIAAA Rockville MD

15. Service AddictologieCHRU Caremeau Nîmes France

16. DISC, Inserm Paris France

17. University RennesINRAEINSERM, CHU RennesInstitute NUMECAN (Nutrition Metabolisms and Cancer) Rennes France

18. APHP, Liver Unit Hospital Jean Verdier Bondy France

19. University Paris 13 Bobigny France

20. Inserm U1162 “Functional Genomics of Solid Tumors,” Paris France

21. Hôpital Antoine‐Béclère Clamart France

22. Hôpital Universitaire Car_Emeau Nîmes France

23. Medical and Research Services VA Long Beach Healthcare System Long Beach CA

24. Translational Genomics Group Inflammatory Bowel & Immunobiology Research Institute Los Angeles CA

25. Drug Health Services Royal Prince Alfred Hospital Camperdown NSW Australia

26. Faculty of Medicine and Health The University of Sydney Sydney NSW Australia

27. Genetic Epidemiology QIMR Berghofer Medical Research Institute Herston QLD Australia

28. Centenary Institute of Cancer Medicine and Cell Biology The University of Sydney Sydney NSW Australia

Funder

National Institute on Alcohol Abuse and Alcoholism

National Health and Medical Research Council

Swiss Foundation for Alcohol Research

Publisher

Wiley

Subject

Hepatology

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