A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia-Reference-Cited by-同舟云学术

A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia

Published:2023-03-24 Issue:15 Volume:10 Page:
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Yi Tingting¹²,Wang Na³⁴,Huang Jing¹,Wang Yaling³,Ren Shuancheng³,Hu Yiwen¹,Xia Jianxia³,Liao Yixiang³,Li Xin³,Luo Fenlan³,Ouyang Qin⁵,Li Yu¹,Zheng Ziyi³,Xiao Qin³,Ren Rong⁶,Yao Zhongxiang³,Tang Xiangdong⁶,Wang Yanjiang⁷,Chen Xiaowei⁸,He Chao³,Li Hong¹,Hu Zhian³⁴⁹^ORCID

Affiliation:

1. Department of Anesthesiology Second Affiliated Hospital Third Military Medical University Chongqing 400037 China

2. Department of Anesthesiology Yongchuan Hospital Chongqing Medical University Chongqing 402160 China

3. Department of Physiology Third Military Medical University Chongqing 400038 China

4. College of Bioengineering Chongqing University Chongqing 400044 China

5. School of Pharmacy Third Military Medical University Chongqing 400038 China

6. Sleep Medicine Center Department of Respiratory and Critical Care Medicine Mental Health Center West China Hospital Sichuan University Chengdu 610041 China

7. Department of Neurology Daping Hospital Third Military Medical University Chongqing 400042 China

8. Brain Research Center Collaborative Innovation Center for Brain Science Third Military Medical University Chongqing 400038 China

9. Chongqing Institute for Brain and Intelligence Guangyang Bay Laboratory Chongqing 400064 China

Abstract

AbstractSevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1+)/cocaine‐ and amphetamine‐regulated transcript (CART+) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1+/CART+ cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1+/CART+ neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1+/CART+ neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202300189

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