Affiliation:
1. Department of Oncology and Molecular Medicine (OMM) Istituto Superiore di Sanità Viale Regina Elena 299 Rome 00161 Italy
2. Dipartimento di Medicina e Chirurgia traslazionale Università Cattolica del Sacro Cuore Largo F. Vito 1 Rome Italy
3. Fondazione Policlinico Universitario “A. Gemelli” – IRCCS Largo F. Vito 1 Rome Italy
Abstract
AbstractThe process of drug discovery and pre‐clinical testing is currently inefficient, expensive, and time‐consuming. Most importantly, the success rate is unsatisfactory, as only a small percentage of tested drugs are made available to oncological patients. This is largely due to the lack of reliable models that accurately predict drug efficacy and safety. Even animal models often fail to replicate human‐specific pathologies and human body's complexity. These factors, along with ethical concerns regarding animal use, urge the development of suitable human‐relevant, translational in vitro models.
Funder
Ministero dell'Università e della Ricerca