Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment
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Published:2024-01-08
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ISSN:2198-3844
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Container-title:Advanced Science
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language:en
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Short-container-title:Advanced Science
Author:
Lei Miao1ORCID,
Wan Haoran1,
Song Jia2,
Lu Yanhui2,
Chang Ronghang1,
Wang Honglei1,
Zhou Hang1,
Zhang Xuehui2,
Liu Changsheng1,
Qu Xue134ORCID
Affiliation:
1. Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of materials science and engineering East China University of Science and Technology Shanghai 200237 China
2. Department of Dental Materials & Dental Medical Devices Testing Center NMPA Key Laboratory for Dental Materials Peking University School and Hospital of Stomatology Beijing 100081 China
3. Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism East China University of Science and Technology Shanghai 200237 China
4. Wenzhou Institute of Shanghai University Wenzhou 325000 China
Abstract
AbstractCurrently available guided bone regeneration (GBR) films lack active immunomodulation and sufficient osteogenic ability‐ in the treatment of periodontitis, leading to unsatisfactory treatment outcomes. Challenges remain in developing simple, rapid, and programmable manufacturing methods for constructing bioactive GBR films with tailored biofunctional compositions and microstructures. Herein, the controlled electroassembly of collagen under the salt effect is reported, which enables the construction of porous films with precisely tunable porous structures (i.e., porosity and pore size). In particular, bioactive salt species such as the anti‐inflammatory drug diclofenac sodium (DS) can induce and customize porous structures while enabling the loading of bioactive salts and their gradual release. Sequential electro‐assembly under pre‐programmed salt conditions enables the manufacture of a Janus composite film with a dense and DS‐containing porous layer capable of multiple functions in periodontitis treatment, which provides mechanical support, guides fibrous tissue growth, and acts as a barrier preventing its penetration into bone defects. The DS‐containing porous layer delivers dual bio‐signals through its morphology and the released DS, inhibiting inflammation and promoting osteogenesis. Overall, this study demonstrates the potential of electrofabrication as a customized manufacturing platform for the programmable assembly of collagen for tailored functions to adapt to specific needs in regenerative medicine.
Funder
National Key Research and Development Program of China
Natural Science Foundation of Beijing Municipality
National Postdoctoral Program for Innovative Talents
National Natural Science Foundation of China
Postdoctoral Research Foundation of China
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)