Unlocking Diabetic Acetone Vapor Detection by A Portable Metal‐Organic Framework‐Based Turn‐On Optical Sensor Device
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Published:2023-11-30
Issue:4
Volume:11
Page:
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ISSN:2198-3844
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Container-title:Advanced Science
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language:en
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Short-container-title:Advanced Science
Author:
Mollick Samraj1ORCID,
Rai Sujeet1,
Frentzel‐Beyme Louis2,
Kachwal Vishal1,
Donà Lorenzo3,
Schürmann Dagmar2,
Civalleri Bartolomeo3,
Henke Sebastian2,
Tan Jin‐Chong1ORCID
Affiliation:
1. Multifunctional Materials & Composites (MMC) Laboratory Department of Engineering Science University of Oxford Parks Road Oxford OX1 UK
2. Anorganische Chemie Fakultät für Chemie & Chemische Biologie Tec‐hnische Universität Dortmund Otto‐Hahn Straße 6 44227 Dortmund Germany
3. Department of Chemistry University of Turin Via Pietro. Giuria 5 Torino 10125 Italy
Abstract
AbstractDespite exhaled human breath having enabled noninvasive diabetes diagnosis, selective acetone vapor detection by fluorescence approach in the diabetic range (1.8–3.5 ppm) remains a long‐standing challenge. A set of water‐resistant luminescent metal‐organic framework (MOF)‐based composites have been reported for detecting acetone vapor in the diabetic range with a limit of detection of 200 ppb. The luminescent materials possess the ability to selectively detect acetone vapor from a mixture comprising nitrogen, oxygen, carbon dioxide, water vapor, and alcohol vapor, which are prevalent in exhaled breath. It is noteworthy that this is the first luminescent MOF material capable of selectively detecting acetone vapor in the diabetic range via a turn‐on mechanism. The material can be reused within a matter of minutes under ambient conditions. Industrially pertinent electrospun luminescent fibers are likewise fabricated alongside various luminescent films for selective detection of ultratrace quantities of acetone vapor present in the air. Ab initio theoretical calculations combined with in situ synchrotron‐based dosing studies uncovered the material's remarkable hypersensitivity toward acetone vapor. Finally, a freshly designed prototype fluorescence‐based portable optical sensor is utilized as a proof‐of‐concept for the rapid detection of acetone vapor within the diabetic range.
Funder
Institute of Advanced Research
Engineering and Physical Sciences Research Council
European Research Council
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)