Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations

Author:

Sun Na12,Tran Benjamin V.3,Peng Zishan4,Wang Jing5,Zhang Ceng1,Yang Peng1,Zhang Tiffany X.1,Widjaja Josephine1,Zhang Ryan Y.1,Xia Wenxi1,Keir Alexandra6,She Jia‐Wei7,Yu Hsiao‐hua7,Shyue Jing‐Jong8,Zhu Hongguang5,Agopian Vatche G.3,Pei Renjun2,Tomlinson James S.3,Toretsky Jeffrey A9,Jonas Steven J.610,Federman Noah6,Lu Shaohua4,Tseng Hsian‐Rong1ORCID,Zhu Yazhen1

Affiliation:

1. California NanoSystems Institute Crump Institute for Molecular Imaging Department of Molecular and Medical Pharmacology University of California, Los Angeles Los Angeles CA 90095 USA

2. Key Laboratory for Nano‐Bio Interface Suzhou Institute of Nano‐Tech and Nano‐Bionics University of Chinese Academy of Sciences Chinese Academy of Sciences Suzhou 215123 P. R. China

3. Department of Surgery University of California, Los Angeles Los Angeles CA 90095 USA

4. Department of Pathology Zhongshan Hospital Fudan University Shanghai 200032 P. R. China

5. Department of Pathology Shanghai Medical College Fudan University Shanghai 200032 P. R. China

6. Department of Pediatrics David Geffen School of Medicine Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Children's Discovery and Innovation Institute University of California, Los Angeles Los Angeles CA 90095 USA

7. Smart Organic Materials Laboratory Institute of Chemistry Academia Sinica Nankang Taipei 115 Taiwan

8. Research Center for Applied Sciences Academia Sinica Nankang Taipei 115 Taiwan

9. Departments of Oncology and Pediatrics Georgetown University Washington DC 20057 USA

10. California NanoSystems Institute Departments of Chemistry and Biochemistry and of Materials Science and Engineering University of California, Los Angeles Los Angeles CA 90095 USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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