Affiliation:
1. Hunan Key Laboratory of Mineral Materials and Application School of Minerals Processing and Bioengineering Central South University Changsha 410083 China
2. Engineering Research Center of Nano‐Geomaterials of Ministry of Education China University of Geosciences Wuhan 430074 China
3. Laboratory of Advanced Mineral Materials China University of Geosciences Wuhan 430074 China
4. Faculty of Materials Science and Chemistry China University of Geosciences Wuhan 430074 China
Abstract
AbstractAdvanced functional two‐dimensional (2D) nanomaterials offer unique advantages in drug delivery systems for disease treatment. Kaolinite (Kaol), a nanoclay mineral, is a natural 2D nanomaterial because of its layered silicate structure with nanoscale layer spacing. Recently, Kaol nanoclay is used as a carrier for controlled drug release and improved drug dissolution owing to its advantageous properties such as surface charge, strong biocompatibility, and naturally layered structure, making it an essential development direction for nanoclay‐based drug carriers. This review outlines the main physicochemical characteristics of Kaol and the modification methods used for its application in biomedicine. The safety and biocompatibility of Kaol are addressed, and details of the application of Kaol as a drug delivery nanomaterial in antibacterial, anti‐inflammatory, and anticancer treatment are discussed. Furthermore, the challenges and prospects of Kaol‐based drug delivery nanomaterials in biomedicine are discussed. This review recommends directions for the further development of Kaol nanocarriers by improving their physicochemical properties and expanding the bioapplication range of Kaol.
Funder
National Science Fund for Distinguished Young Scholars
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
6 articles.
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