Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis

Author:

Gao Jianing1,Chen Yanghui2,Wang Huiqing1,Li Xin1,Li Ke3,Xu Yangkai1,Xie Xianwei4,Guo Yansong5,Yang Nana6,Zhang Xinhua7,Ma Dong8,Lu Hong S.9ORCID,Shen Ying H.10,Liu Yong11,Zhang Jifeng12,Chen Y. Eugene12,Daugherty Alan9,Wang Dao Wen2,Zheng Lemin1313ORCID

Affiliation:

1. The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Science of Ministry of Education NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing Key Laboratory of Cardiovascular Receptors Research Health Science Center Peking University Beijing 100191 P. R. China

2. Division of Cardiology Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Jiefang Avenue NO.1095, Qiaokou District Wuhan 430000 P. R. China

3. Beijing Tiantan Hospital China National Clinical Research Center for Neurological Diseases Advanced Innovation Center for Human Brain Protection Beijing Institute of Brain Disorders The Capital Medical University Beijing 100050 P. R. China

4. Department of Cardiology Shengli Clinical Medical College of Fujian Medical University Fujian Provincial Hospital Fuzhou 350001 P. R. China

5. Department of Cardiology Shengli Clinical Medical College of Fujian Medical University Fujian Provincial Hospital Fujian Provincial Key Laboratory of Cardiovascular Disease Fujian Provincial Center for Geriatrics Fujian Clinical Medical Research Center for Cardiovascular Diseases Fujian Heart Failure Center Alliance Fuzhou 350001 P. R. China

6. Weifang Key Laboratory of Animal Model Research on Cardiovascular and Cerebrovascular Diseases Weifang Medical University Weifang 261053 P. R. China

7. Department of Biochemistry and Molecular Biology The Key Laboratory of Neural and Vascular Biology Ministry of Education Hebei Medical University Zhongshan East Road No. 361 Shijiazhuang 050017 P. R. China

8. Department of Biochemistry and Molecular Biology The Key Laboratory of Neural and Vascular Biology China Administration of Education Hebei Medical University Hebei 050017 P. R. China

9. Department of Physiology Saha Cardiovascular Research Center University of Kentucky South Limestone Lexington KY 40536‐0298 USA

10. Division of Cardiothoracic Surgery Michael E. DeBakey Department of Surgery Baylor College of Medicine Department of Cardiovascular Surgery Texas Heart Institute Houston TX 77030 USA

11. Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Institute for Advanced Studies Wuhan University Wuhan 430072 P. R. China

12. Department of Internal Medicine University of Michigan Medical Center Ann Arbor MI 48109 USA

13. Hangzhou Qianjiang Distinguished Expert Hangzhou Institute of Advanced Technology Hangzhou 310026 P. R. China

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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