Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation-Reference-Cited by-同舟云学术

Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation

Published:2022-05-07 Issue:20 Volume:9 Page:2200742
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Lin Huige¹,Wang Lin¹²³,Liu Zhuohao²³⁴,Long Kekao¹,Kong Mengjie¹,Ye Dewei⁵,Chen Xi¹,Wang Kai¹,Wu Kelvin KL¹,Fan Mengqi⁵,Song Erfei⁶,Wang Cunchuan⁶,Hoo Ruby LC²⁷,Hui Xiaoyan²³,Hallenborg Philip⁸,Piao Hailong⁹,Xu Aimin²³⁷^ORCID,Cheng Kenneth KY¹^ORCID

Affiliation:

1. Department of Health Technology and Informatics The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong

2. The State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong Pokfulam Hong Kong

3. Department of Medicine The University of Hong Kong Pokfulam Hong Kong

4. Department of Neurosurgery Shenzhen Hospital Southern Medical University Shenzhen 518000 P. R. China

5. Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education Guangdong Pharmaceutical University Guangzhou 510000 P. R. China

6. Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University Guangzhou 510000 P. R. China

7. Department of Pharmacology and Pharmacy The University of Hong Kong Pokfulam Hong Kong

8. Department of Biochemistry and Molecular Biology University of Southern Denmark Southern Denmark 5230 Denmark

9. Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116000 P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202200742

Reference46 articles.

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2. Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

3. MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease

4. Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

5. Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

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