CO2‐DBU‐Triggered Photoredox‐Catalyzed Direct α‐C‐H Alkylation of Alcohols

Abstract

AbstractAn efficient photoinduced and metal‐free method for direct α‐C–H monoalkylation of alcohols utilizing the CO2‐DBU‐system as a hydrogen bond acceptor (HBA) catalyst in the presence of water (H2O) is reported. This protocol allows for selective functionalization of alcohols with a broad substrate scope, demonstrating yields up to 88% in 36 examples. Systematic computational analysis using DFT calculations reveals insights into the mechanism by identifying the key intermediates assembled via intermolecular hydrogen bond between DBU‐CO2 adduct and alcohol. This strategy opens new avenues for efficient alkylation of ordinary alcohols, offering an environmentally friendly approach to complex molecular synthesis.