Activation of cGAS‐STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b + Ly6C hi Proinflammatory Monocytes

Author:

Du Yang12,Luo Yien123,Hu Zhiqiang4,Lu Jiansen45,Liu Xin12,Xing Changsheng12,Wu Jian6,Duan Tianhao12,Chu Junjun12,Wang Helen Y.172,Su Xin‐zhuan6,Yu Xiao452,Wang Rong‐Fu172

Affiliation:

1. Department of Medicine and Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA 90033 USA

2. Center for Inflammation and Epigenetics Houston Methodist Research Institute Houston TX 77030 USA

3. Department of Neurology Xiangya Hospital Central South University Changsha Hunan 410008 China

4. Department of Immunology Guangdong Provincial Key Lab of Single Cell Technology and Application School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong 510515 China

5. Department of Joint Surgery The Fifth Affiliated Hospital Southern Medical University Guangzhou Guangdong 510515 China

6. Malaria Functional Genomics Section Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD 20892 USA

7. Department of Pediatrics Children's Hospital Keck School of Medicine University of Southern California Los Angeles CA 90027 USA

Funder

National Natural Science Foundation of China

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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