Affiliation:
1. Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA
2. Department of Bioengineering University of California Los Angeles CA 90095 USA
3. California NanoSystems Institute University of California Los Angeles CA 90095 USA
4. Mork Family Department of Chemical Engineering & Materials Science Viterbi School of Engineering University of Southern California Los Angeles CA 90007 USA
5. Electrical and Computer Engineering Department University of British Columbia Vancouver BC V6T 1Z4 Canada
6. College of Pharmacy Korea University Sejong 30019 Republic of Korea
Abstract
AbstractDeveloping theranostic devices to detect bleeding and effectively control hemorrhage in the prehospital setting is an unmet medical need. Herein, an all‐in‐one theranostic platform is presented, which is constructed by sandwiching silk fibroin (SF) between two silver nanowire (AgNW) based conductive electrodes to non‐enzymatically diagnose local bleeding and stop the hemorrhage at the wound site. Taking advantage of the hemostatic property of natural SF, the device is composed of a shape‐memory SF sponge, facilitating blood clotting, with ≈82% reduction in hemostatic time in vitro as compared with untreated blood. Furthermore, this sandwiched platform serves as a capacitive sensor that can detect bleeding and differentiate between blood and other body fluids (i.e., serum and water) via capacitance change. In addition, the AgNW electrode endows anti‐infection efficiency against Escherichia coli and Staphylococcus aureus. Also, the device shows excellent biocompatibility and gradually biodegrades in vivo with no major local or systemic inflammatory responses. More importantly, the theranostic platform presents considerable hemostatic efficacy comparable with a commercial hemostat, Dengen, in rat liver bleeding models. The theranostic platform provides an unexplored strategy for the intelligent management of hemorrhage, with the potential to significantly improve patients' well‐being through the integration of diagnostic and therapeutic capabilities.
Funder
National Institutes of Health
University of California, Los Angeles
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
1 articles.
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