Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice-Reference-Cited by-同舟云学术

Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice

Published:2023-08-06 Issue:27 Volume:10 Page:
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Yang Xue¹²³⁴,Zong Chen³⁴,Feng Chao¹²,Zhang Cangang⁵,Smirnov Artem²,Sun Gangqi⁶,Shao Changchun⁷,Zhang Luyao⁶,Hou Xiaojuan³⁴,Liu Wenting³⁴,Meng Yan³⁴,Zhang Liying¹,Shao Changshun¹,Wei Lixin³⁴^ORCID,Melino Gerry²,Shi Yufang¹

Affiliation:

1. The Third Affiliated Hospital of Soochow University Institutes for Translational Medicine State Key Laboratory of Radiation Medicine and Protection Key Laboratory of Stem Cells and Medical Biomaterials of Jiangsu Province Medical College of Soochow University Soochow University Suzhou 215000 China

2. Department of Experimental Medicine TOR University of Rome Tor Vergata Rome 00133 Italy

3. Department of Tumor Immunology and Gene Therapy Center Third Affiliated Hospital of Naval Medical University Shanghai 200438 China

4. Department of immunology and metabolism National Center for Liver Cancer Shanghai 201805 China

5. Department of Pathogenic Microbiology and Immunology School of Basic Medical Sciences Xi'an Jiaotong University Xi'an Shaanxi 710061 China

6. Department of Clinical Pharmacology The Second Hospital of Anhui Medical University Hefei 230601 China

7. Department of Oncology The First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China

Abstract

AbstractAging is always accompanied by chronic diseases which probably attribute to long‐term chronic inflammation in the aging body. Whereas, the mechanism of chronic inflammation in aging body is still obscure. Mesenchymal stem cells (MSCs) are capable of local chemotaxis to sites of inflammation and play a powerful role in immune regulation. Whether degeneration of MSCs in the aging body is associated with unbalanced inflammation is still not clear. In this study, immunosuppressive properties of aged MSCs are found to be repressed. The impaired immunosuppressive function of aged MSCs is associated with lower expression of the Hippo effector Yes‐associated protein 1 (YAP1) and its target gene signal transducer and activator of transcription 1 (STAT1). YAP1 regulates the transcription of STAT1 through binding with its promoter. In conclusion, a novel YAP1/STAT1 axis maintaining immunosuppressive function of MSCs is revealed and impairment of this signal pathway in aged MSCs probably resulted in higher inflammation in aged mice liver.

Funder

National Natural Science Foundation of China

Shanghai Municipal Health Bureau

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202300424

Reference91 articles.

1. Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes

2. Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

3. Inflammation in Atherosclerosis

4. Arterial calcification: A review of mechanisms, animal models, and the prospects for therapy

5. Increased Pulse Wave Velocity Associated with Reduced Calcaneal Quantitative Osteo-sono Index: Possible Relationship Between Atherosclerosis and Osteopenia