Surface Acoustic Wave‐Enhanced Multi‐View Acoustofluidic Rotation Cytometry (MARC) for Pre‐Cytopathological Screening

Author:

Zhang Xiaoyan12,Dumčius Povilas1,Mikhaylov Roman1,Qi Jiangfa2,Stringer Mercedes1,Sun Chao3,Nguyen Van Dien45,Zhou You45,Sun Xianfang6,Liang Dongfang7,Liu Dongge8,Yan Bing9,Feng Xi10,Mei Changjun11,Xu Cong11,Feng Mingqian2,Fu Yongqing12,Clayton Aled13,Zhi Ruicong1415,Tian Liangfei16,Dong Zhiqiang2,Yang Xin1ORCID

Affiliation:

1. Department of Electrical and Electronic Engineering, School of Engineering Cardiff University Cardiff CF24 3AA UK

2. International Joint Laboratory of Biomedicine and Engineering College of Biomedicine and Health College of Life Science and Technology Huazhong Agricultural University Wuhan 430070 P. R. China

3. School of Life Sciences Northwestern Polytechnical University Xi'an 710072 P. R. China

4. Systems Immunity University Research Institute Cardiff University Cardiff CF14 4XN UK

5. Division of Infection and Immunity Cardiff University Cardiff CF14 4XN UK

6. School of Computer Science and Informatics Cardiff University Cardiff CF24 4AG UK

7. Department of Engineering University of Cambridge Cambridge CB2 1PZ UK

8. Department of Pathology Beijing Hospital Beijing 100730 P. R. China

9. Department of Information Management Beijing Hospital Beijing 100730 P. R. China

10. Department of Pathology Hubei Cancer Hospital Wuhan 430079 P. R. China

11. Department of Pathology Xiangzhou District People's Hospital of Xiangyang Xiangyang 441000 P. R. China

12. Faculty of Engineering and Environment Northumbria University Newcastle Upon Tyne NE1 8ST UK

13. School of Medicine Cardiff University Cardiff CF14 4XN UK

14. School of Computer and Communication Engineering University of Science and Technology Beijing Beijing 100083 P. R. China

15. Beijing Key Laboratory of Knowledge Engineering for Materials Science Beijing 100083 P.R. China

16. Department of Biomedical Engineering MOE Key Laboratory of Biomedical Engineering Zhejiang University Hangzhou 310027 P. R. China

Abstract

AbstractCytopathology, crucial in disease diagnosis, commonly uses microscopic slides to scrutinize cellular abnormalities. However, processing high volumes of samples often results in numerous negative diagnoses, consuming significant time and resources in healthcare. To address this challenge, a surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) technique is developed for pre‐cytopathological screening. MARC enhances cellular morphology analysis through comprehensive and multi‐angle observations and amplifies subtle cell differences, particularly in the nuclear‐to‐cytoplasmic ratio, across various cell types and between cancerous and normal tissue cells. By prioritizing MARC‐screened positive cases, this approach can potentially streamline traditional cytopathology, reducing the workload and resources spent on negative diagnoses. This significant advancement enhances overall diagnostic efficiency, offering a transformative vision for cytopathological screening.

Publisher

Wiley

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