Affiliation:
1. Department of Microbiota Medicine & Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China
2. Key Lab of Holistic Integrative Enterology Nanjing Medical University Nanjing 210011 China
3. Department of Microbiota Medicine Sir Run Run Hospital Nanjing Medical University Nanjing 211166 China
Abstract
AbstractFecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for dysbiosis‐related diseases. However, the clinical practice of crude fecal transplants presents limitations in terms of acceptability and reproductivity. Consequently, two alternative solutions to FMT are developed: transplanting bacteria communities or virome. Advanced methods for transplanting bacteria mainly include washed microbiota transplantation and bacteria spores treatment. Transplanting the virome is also explored, with the development of fecal virome transplantation, which involves filtering the virome from feces. These approaches provide more palatable options for patients and healthcare providers while minimizing research heterogeneity. In general, the evolution of the next generation of FMT in global trends is fecal microbiota components transplantation which mainly focuses on transplanting bacteria or virome.
Funder
National Key Research and Development Program of China
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)