Ureido‐Ionic Liquid Mediated Conductive Hydrogel: Superior Integrated Properties for Advanced Biosensing Applications

Author:

Ji Ruiying123,Yan Shaopeng123,Zhu Zhiyu123,Wang Yaping123,He Dan123,Wang Kaikai123,Zhou Daofeng123,Jia Qike23,Wang Xiuxiu4,Zhang Botao123,Shi Changcheng123,Xu Ting23,Wang Rong23,Wang Rui5,Zhou Yang123ORCID

Affiliation:

1. Cixi Biomedical Research Institute Wenzhou Medical University Ningbo 315300 China

2. Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315300 China

3. Ningbo Cixi Institute of Biomedical Engineering Ningbo 315300 China

4. Chemistry and Biomedicine Innovation Center (ChemBIC), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China

5. Pingshan Translational Medicine Center Shenzhen Bay Laboratory Shenzhen 518118 China

Abstract

AbstractIonic conductive hydrogels (ICHs) have recently gained prominence in biosensing, indicating their potential to redefine future biomedical applications. However, the integration of these hydrogels into sensor technologies and their long‐term efficacy in practical applications pose substantial challenges, including a synergy of features, such as mechanical adaptability, conductive sensitivity, self‐adhesion, self‐regeneration, and microbial resistance. To address these challenges, this study introduces a novel hydrogel system using an imidazolium salt with a ureido backbone (UL) as the primary monomer. Fabricated via a straightforward one‐pot copolymerization process that includes betaine sulfonate methacrylate (SBMA) and acrylamide (AM), the hydrogel demonstrates multifunctional properties. The innovation of this hydrogel is attributed to its robust mechanical attributes, outstanding strain responsiveness, effective water retention, and advanced self‐regenerative and healing capabilities, which collectively lead to its superior performance in various applications. Moreover, this hydrogel  exhibited broad‐spectrum antibacterial activity. Its potential for biomechanical monitoring, especially in tandem with contact and noncontact electrocardiogram (ECG) devices, represents a noteworthy advancement in precise real‐time cardiac monitoring in clinical environments. In addition, the conductive properties of the hydrogel make it an ideal substrate for electrophoretic patches aimed at treating infected wounds and consequently enhancing the healing process.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Science and Technology Innovation 2025 Major Project of Ningbo

Publisher

Wiley

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