Affiliation:
1. Institute for Immunology and School of Medicine Tsinghua University and Tsinghua‐Peking Center for Life Sciences Beijing 100084 China
2. Department of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi Guizhou 563000 China
3. SXMU‐Tsinghua Collaborative Innovation Center for Frontier Medicine Taiyuan 030001 China
4. Beijing Key Laboratory for Immunological Research on Chronic Diseases Beijing 100084 China
Abstract
AbstractSympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important functions in metabolic activities. Additionally, the immune system has long been studied for its essential roles in metabolic health and diseases. In this review, the aim is to provide an overview of the current research progress on the sympathetic regulation of key metabolic organs, including the pancreas, liver, intestine, and adipose tissues. In particular, efforts are made to highlight the critical roles of the peripheral nervous system and its potential interplay with immune components. Overall, it is hoped to underscore the importance of studying metabolic organs from a comprehensive and interconnected perspective, which will provide valuable insights into the complex mechanisms underlying metabolic regulation and may lead to novel therapeutic strategies for metabolic diseases.
Funder
Beijing Municipal Natural Science Foundation
National Natural Science Foundation of China
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)