Affiliation:
1. Department of Radiology Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital Changwon Republic of Korea
2. Department of Radiology Institute of Health Sciences, Gyeongsang National University School of Medicine Jinju Republic of Korea
3. Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital Changwon Republic of Korea
4. Department of Thoracic and Cardiovascular Surgery Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital Yangsan‐si Republic of Korea
Abstract
AbstractPurposeThe purpose of this study was to assess the prevalence and clinical implications of false‐positive supraclavicular lymph node (LN) detected on chest computed tomography (CT), using subsequent neck ultrasonography (US) and US‐guided tissue sampling.MethodsAmong 172 patients with suspected supraclavicular LNs identified on CT, 87 underwent neck US or US‐guided tissue sampling. Receiver operating characteristic curve and logistic regression analyses were performed to determine the diagnostic performance of US and independent predictors of false‐positive LNs.ResultsAmong 87 patients, 49 (56.3%) were pathologically confirmed as metastases, 26 (29.9%) were negative for malignancy, and 12 (13.8%) had pseudolesions or schwannomas. The diagnostic indices were as follows: sensitivity, 91.8%; specificity, 92.3%; PPV, 95.7%; NPV, 85.7%; and accuracy, 92.0% (AUC = 0.921; 95% CI: 0.832–0.970, p < 0.001). The false‐positive group had a higher mean age than the true‐positive group (mean age, 69.8 ± 9.2 vs. 63.9 ± 9.8, p = 0.003). Logistic regression analyses revealed that age ≥ 65 years was the only independent predictor of false‐positive LNs (OR = 4.391; 95% CI: 1.037–18.582; p = 0.044).ConclusionSubsequent US can be helpful for evaluating suspicious supraclavicular LNs detected on CT to establish appropriate management, especially in older patients.
Subject
Radiology, Nuclear Medicine and imaging
Cited by
1 articles.
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