The role of receptor‐type protein tyrosine phosphatases in cancer-Reference-Cited by-同舟云学术

The role of receptor‐type protein tyrosine phosphatases in cancer

Published:2023-01-02 Issue:1 Volume:12 Page:48-57
ISSN:2642-2514
Container-title:Precision Medical Sciences
language:en
Short-container-title:Precision Medical Sciences

Author:

Lv Zhengyuan¹,Wang Tianming¹²^ORCID,Cao Xin¹,Sun Mengting³^ORCID,Qu Yuan⁴^ORCID

Affiliation:

1. Department of Medical Genetics, School of Basic Medical Science Nanjing Medical University Nanjing China

2. Central Laboratory, Translational Medicine Research Center The Affiliated Jiangning Hospital with Nanjing Medical University Nanjing China

3. Biobank of Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China

4. Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China

Abstract

AbstractReceptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers.

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prm2.12090

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5. Receptor type protein tyrosine phosphatases (RPTPs) – roles in signal transduction and human disease