The application of aptamers in the field of aging and age‐related diseases

Author:

Xu LiuJun1,Jiang Beier1,Qiu WenJing1,Jiang Chunxia1,Zhang Feng1,Tan Weihong234

Affiliation:

1. Joint Innovation Center for Engineering in Medicine Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou China

2. Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University Changsha Hunan China

3. The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Hangzhou Institute of Medicine (HIM) Zhejiang Cancer Hospital, Chinese Academy of Sciences Hangzhou Zhejiang China

4. Institute of Molecular Medicine (IMM) Renji Hospital Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University Shanghai China

Abstract

AbstractThe world is transitioning into an aging society, a phenomenon that escalates the risk of age‐related diseases, posing a significant threat to human health. Addressing how to delay aging or achieve healthy aging has become an urgent and pivotal issue. Presently, diverse anti‐aging drugs are under development and entering clinical validation stages. However, the absence of specific aging biomarkers has hindered the identification of corresponding targets for diagnosing and treating aging and age‐related diseases. Aptamer, a novel molecular recognition tool, has found broad application in diagnosing and treating various diseases. Additionally, cell‐based selection holds the potential to identify unidentified molecules that could serve as biomarkers for diseases. Recent years have seen a surge in attention towards aging and age‐related diseases, with the application of aptamer in this domain rapidly advancing. Consequently, this review will provide a concise overview of the aging, with a focus on the utilisation of aptamer in aging and age‐related diseases.

Publisher

Wiley

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