Affiliation:
1. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy Cairo University Cairo Egypt
Abstract
AbstractThe N‐acylhydrazone motif has been shown to be particularly adaptable and promising in the area of medicinal chemistry and drug development, due to its significant biological and pharmacological characteristics. Moreover, N‐acylhydrazones are appealing synthetic and biological tools because of their simple and straightforward synthesis. This scaffold has emerged as a fundamental building block for the synthesis of bioactive compounds. Particularly, the N‐acylhydrazone scaffold served as a base for the synthesis of a number of potent anticancer agents acting via different mechanisms. An updated summary of the anticancer activity of N‐acylhydrazone derivatives described in the literature (from 2017 to 2022) is provided in the current review. It discusses the structure–activity relationship (SAR) of N‐acylhydrazone derivatives exhibiting anticancer potential, which could be helpful in designing and developing new derivatives as effective antiproliferative candidates in the future.
Subject
Drug Discovery,Pharmaceutical Science
Cited by
2 articles.
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