Identification of multiple components in Guanxinning injection using hydrophilic interaction liquid chromatography/time-of-flight mass spectrometry and reversed-phase liquid chromatography/time-of-flight mass spectrometry

Author:

Chen Xiaofei12,Lou Ziyang12,Zhang Hai3,Tan Guangguo12,Liu Zhirui12,Li Wuhong12,Zhu Zhenyu12,Chai Yifeng12

Affiliation:

1. Department of Pharmaceutical Analysis; School of Pharmacy; Second Military Medical University; Shanghai 200433 China

2. Shanghai Key Laboratory for Pharmaceutical Metabolite Research; Shanghai 200433 China

3. Department of Pharmacy; Eastern Hepatobiliary Surgery Hospital; Shanghai 200438 China

Funder

ZhenTaiDongSheng Pharmaceutical Co., Ltd

National Natural Science Fund of China

Project of Modernization of Traditional Chinese Medicine of Shanghai

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference43 articles.

1. SFDA[2009]359 A notification on the implemention of “safety re-evaluation of tradition Chinese medicine injections” 2009 http://www.sda.gov.cn/WS01/CL0055/39880.html

2. Analysis of Chinese herbal medicines with holistic approaches and integrated evaluation models;Li;Trends Anal. Chem.,2008

3. Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats;Chang;Acta Pharmacol. Sin.,2010

4. Danshen (Salvia miltiorrhiza) extract inhibits proliferation of breast cancer cells via modulation of Akt activity and p27 level;Yang;Phytother. Res.,2010

5. Mechanisms of the relaxant effect of a Danshen and Gegen formulation on rat isolated cerebral basilar artery;Lam;J. Ethnopharmacol.,2010

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