Affiliation:
1. College of Chemical Engineering Nanjing Forestry University Nanjing 210037 People's Republic of China
2. School of Chemistry Monash University Clayton Victoria 3800 Australia
Abstract
AbstractA new strategy for thiochromen‐4‐one synthesis that relies on the denitrative formal [5+1] cycloaddition of 1‐(2‐nitrophenyl)‐2‐yn‐1‐ones with thioacetamide is described. Achieved under reaction conditions that did not require transition metal catalysis, nor the exclusion of air or moisture, the reaction is suggested to involve exploiting the propensity of thioacetamide to undergo hydrolysis under basic conditions. This is follows by addition of the ensuing sulfide anion to the 1,3‐alkynone and a nucleophilic aromatic substitution and denitrative rearomatization cascade to give the S‐heterocyclic product in yields of 41–99 %.