Affiliation:
1. College of Pharmacy Jiangxi University of Chinese Medicine Meiling Avenue Nanchang 330004 China
2. Key Laboratory of Marine Genetic Resources Third Institute of Oceanography Ministry of Natural Resources 184 Daxue Road Xiamen 361005 China
3. College of Ocean Food and Biological Engineering Jimei University 43 Yindou Road Xiamen 361021 China
Abstract
AbstractThree new sesquiterpene‐hydroquinone hybrids, saromacrophorins A–C (1–3) were isolated from the deep‐sea‐derived fungus Sarocladium terricola 494a, along with nine known compounds. Their structures were elucidated by comprehensive analyses of 1D and 2D NMR, HRESIMS, and ECD calculations. Noteworthily, compound 1 is a rare 5′,6′‐dihydroxymacrophorin and compound 3 is the first example of macrophorin possessing 4′S‐configuration. Compound 4 showed potent anti‐food allergic activity with an IC50 value of 18.9 μM.
Funder
Xiamen Southern Oceanographic Center
Subject
Organic Chemistry,Physical and Theoretical Chemistry