Catalyst‐Free Regioselective C3−H Benzoxylation of 1<i>H</i>‐Indoles with Benzoyl Peroxide-Reference-Cited by-同舟云学术

Catalyst‐Free Regioselective C3−H Benzoxylation of 1H‐Indoles with Benzoyl Peroxide

Published:2023-10-23 Issue:44 Volume:26 Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Pilli Navyasree¹²,Karu Sudheer Kumar¹²,Malapaka Chandrasekharam¹²^ORCID

Affiliation:

1. Polymers & Functional materials CSIR-Indian Institute of Chemical Technology Tarnaka Hyderabad 500 007 India

2. Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India

Abstract

AbstractAn efficient catalyst‐free C−O bond formation reaction for the synthesis of 1H‐indol‐3‐yl benzoates was developed through C(sp2)−H functionalization of 1H‐indoles with benzoyl peroxide (BPO) in acetonitrile at room temperature under open flask conditions. The reaction proceeds without exclusion of air or moisture and is applied to a wide array of electronically differentiated indoles as well as BPOs. C3 benzoxylation of indoles was achieved with excellent regioselectivity under mild and easy to operate conditions. The reaction is scalable to one gram level.

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

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