Affiliation:
1. Department of Chemistry Faculty of Engineering and Technology SRM Institute of Science and Technology SRM Nagar Kattankulathur 603 203, Chengalpattu District Tamil Nadu India
Abstract
AbstractHighly functionalized quinazolin‐4(3H)‐ones were synthesized from reactions of N‐aryl‐2‐aminobenzamides with trialkylamines under photocatalytic conditions by using eosin Y (EY) as a catalyst. The reaction proceeds under mild conditions in aqueous acetonitrile and has a broad substrate scope. Mechanistic studies disclosed the electron‐donor nature of the intermediate 2,3‐dihydroquinazolin‐4(1H)‐one (3’) in the photocatalytic cycle to afford the 2,3‐disubstituted‐quinazolin‐4(3H)‐ones (3). This methodology has been extended to synthesize benzo [4,5] imidazole[1,2‐c] quinazolines and 3 aa on a large scale. Furthermore, the synthesis of potent central nervous system depressant (CNS) drug molecules such as methaqualone (3 la) and mecloqualone (3 pa) was also achieved successfully.
Funder
SRM Institute of Science and Technology
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
5 articles.
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