KO‐t‐Bu Catalyzed Thiolation of β‐(Hetero)arylethyl Ethers via MeOH Elimination/hydrothiolation

Abstract

AbstractHerein, we describe a KO‐t‐Bu catalyzed thiolation of β‐(hetero)arylethyl ethers through MeOH elimination to form (hetero)arylalkenes followed by anti‐Markovnikov hydrothiolation to afford linear thioethers. The system works well with a variety of β‐(hetero)arylethyl ethers, including electron‐deficient, electron‐neutral, electron‐rich, and branched substrates and a range of aliphatic and aromatic thiols.