Affiliation:
1. Department of Dermatology & Venerology and State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu 610041 P. R. China
Abstract
AbstractCross‐electrophile coupling reactions are efficient for the construction of carbon‐carbon bonds under relatively mild conditions, and hence widely used for making new molecules. Among various electrophiles, the cross‐electrophile coupling reaction between two different tosylates has been rarely studied. Herein, we present a cross‐electrophile coupling of gem‐difluoroalkenyl tosylate (C(sp2)−OTs) and α‐CF3 benzyl tosylate (C(sp3)−OTs) by nickel/palladium cooperative catalysis. Mechanistic investigation indicated that the activation of C(sp2)−OTs bond and C(sp3)−OTs bond was facilitated by nickel and palladium respectively.
Funder
National Natural Science Foundation of China
Sichuan University
Subject
Organic Chemistry,Physical and Theoretical Chemistry