Affiliation:
1. Polymer Science & Technology Department CSIR-Central Leather Research Institute Chennai 600 020 India
2. Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India
3. Biochemistry & Biotechnology Lab Department CSIR-Central Leather Research Institute Chennai 600 020 India
Abstract
AbstractClick reaction or copper‐assisted azide–alkyne cycloaddition (CuAAC) reaction can conveniently synthesize desired organic molecules or functionalize biological macromolecules. In many cases, trace amounts of residual copper from the reaction mixture are not trivial to remove when the exhaustive purification step is avoided to fulfill the essential criteria of a click reaction. It is often detrimental, particularly for biochemical applications or when it involves biological macromolecules. Herein, we have reported the synthesis of a new type of copper (I) complex as a smart catalyst for click reaction, which can be separated from the reaction mixture very easily by the slight elevation of temperature, thanks to its thermoresponsive behavior. The click reactions using a thermoresponsive catalyst were first studied in an aqueous medium using various organic molecules containing alkyne and azide functional groups. Later, the strategy was extended to biological macromolecules like collagen.
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
1 articles.
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