Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression

Author:

Wu Min-Hua12,Chiu Yi-Fang1,Wu Wen-Jun2,Wu Pei-Lien3,Lin Ching-Yi4,Lin Chia-Liang5,Hsieh Yi-Hsien567ORCID,Liu Chung-Jung38

Affiliation:

1. Department of Laboratory, Chung-Kang Branch; Cheng-Ching General Hospital; Taichung Taiwan

2. Institute of Medicine, Chung Shan Medical University; Taichung Taiwan

3. Division of Gastroenterology, Department of Internal Medicine; Kaohsiung Medical University Hospital; Kaohsiung Taiwan

4. Division of Chest Medicine, Department of Internal Medicine; Taichung Veterans General Hospital; Taichung Taiwan

5. Institute of Biochemistry, Microbiology and Immunology; Chung Shan Medical University; Taichung Taiwan

6. Department of Biochemistry, School of Medicine; Chung Shan Medical University; Taichung Taiwan

7. Clinical Laboratory; Chung Shan Medical University Hospital; Taichung Taiwan

8. Center for Stem Cell Research; Kaohsiung Medical University; Kaohsiung Taiwan

Funder

Chung-Kang Branch, Cheng-Ching General Hospital Research Fund

Kaohsiung Medical University

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine

Reference45 articles.

1. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics;Dhanasekaran;Hepatic Med.,2012

2. Hepatocellular carcinoma;Forner;Lancet.,2012

3. Drug delivery system targeting advanced hepatocellular carcinoma: current and future;Zhang;Nanomedicine.,2016

4. Genes that regulate metastasis and angiogenesis;Webb;J Neurooncol.,2000

5. Systemic therapy for advanced hepatocellular carcinoma: an update;Desai;J Gastrointest Oncol.,2017

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