Affiliation:
1. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo 4-6-1 Komaba, Meguro Tokyo 153-8904 Japan
2. Department of Applied Chemistry, School of Engineering Tokyo University of Technology 1404-1 Katakuramachi Hachioji City, Tokyo 192-0982 Japan
Abstract
AbstractTherapeutic nucleic acid drugs (antisense DNA, siRNA, DNAzyme, and others) have been widely employed to regulate the expression of a disease‐causing gene. For the correction of a gene, the CRISPR/Cas9 system is available. Advantageously, they can be straightforwardly designed in terms of the Watson‐Crick rule. In order to deliver these nucleic acid drugs to a target place in our body (organs and cells) at desired timing, various nanoarchitectures have been elegantly designed. Their primary roles are protection of drugs from degradation, increase of cell‐membrane permeability, and spatiotemporal control of delivery. Encapsulated nucleic acid drugs are released by decomposing the nanostructures with either external stimuli or intracellular signals. Furthermore, therapeutic efficiency is enhanced by simultaneously delivering multiple types of nucleic acid drugs for their cooperation. Composites of nanoarchitectures and therapeutic nucleic acid drugs are highly promising for future applications.
Subject
Materials Chemistry,Energy Engineering and Power Technology,Renewable Energy, Sustainability and the Environment,Biomaterials
Cited by
1 articles.
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