Affiliation:
1. Department of Ultrasound Zhongda Hospital Medical School Southeast University Nanjing 210009 P. R. China
2. Department of Ultrasound Suzhou Municipal Hospital Suzhou Hospital Nanjing Medical University Suzhou 215001 P. R. China
3. Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China
Abstract
Sonopiezoelectric therapy (SPT) has gained ever‐increasing prominence in tumor therapy as a combination of ultrasound (US) and piezoelectric nanomaterials to generate cytotoxic reactive oxygen species (ROS) for tumor suppression. In this study, the facile hydrothermal method is used to construct the distinct 2D piezocatalyst Bi2Fe4O9 nanosheets (BFO NSs). The engineered BFO NSs can create a piezoelectric field when exposed to US irradiation, facilitating the separation of electron–hole (e−–h+) pairs to play a crucial role in Fe3+/Fe2+ circulation, which catalyzes the activation of peroxymonosulfate (PMS), resulting in an amplified production of cytotoxic sulfate radical (SO4•−). The produced SO4•− combines with ROS generated by SPT including hydroxyl radicals (•OH), and singlet oxygen (1O2), leading to the augmented oxidative tumor suppression. The BFO NSs and PMS are further integrated into a thermal hydrogel (BFO/PMS‐Gel) for in vitro and in vivo investigations on their catalytic antitumor effects. In both in vitro and in vivo studies, it is validated that BFO/PMS‐Gel, under US irradiation, significantly enhances radicals generation efficiency, which achieves superior antitumor performance while maintaining high therapeutic biocompatibility and biosafety, providing a representative paradigm of US‐activated multiple radicals production as enabled by piezoelectric nanomedicine for antitumor treatment.
Funder
National Natural Science Foundation of China
Subject
General Earth and Planetary Sciences,General Environmental Science