Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters-Reference-Cited by-同舟云学术

Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

Published:2017-02-17 Issue:4 Volume:101 Page:501-509
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Yang K¹,Battista C¹²,Woodhead JL¹,Stahl SH³,Mettetal JT⁴,Watkins PB²,Siler SQ¹,Howell BA¹

Affiliation:

1. DILIsym Services IncResearch Triangle Park North Carolina USA

2. University of North Carolina Institute for Drug Safety SciencesThe Eshelman School of Pharmacy, The University of North Carolina at Chapel HillChapel Hill North Carolina USA

3. ADME TransportersDrug Safety and Metabolism, Innovative Medicines and Early Development, AstraZenecaCambridge United Kingdom

4. Drug Safety and MetabolismAstraZeneca R&DWaltham Massachusetts USA

Funder

U.S. Food and Drug Administration

Oak Ridge Institute for Science and Education

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.619

Reference49 articles.

1. U.S. Food and Drug Administration Guidance for Industry Drug‐Induced Liver Injury: Premarketing Clinical Evaluation. . (2009).

2. Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period

3. Outcome and prognostic markers in severe drug-induced liver disease

4. Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin

5. Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6

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