Affiliation:
1. College of Biomedical Engineering Taiyuan University of Technology Taiyuan 030024 P. R. China
Abstract
AbstractAtherosclerosis is induced by the persistent inflammation of the arterial wall. The regulation of inflammation through active drugs can mitigate atherosclerotic lesions, but the therapeutic outcome is limited due to its insufficient efficacy and stability. Herein, a PdH‐Te nanozyme with excellent reactive oxygen species (ROS) scavenging capability is designed for anti‐inflammatory therapy, thereby preventing foam cell formation to alleviate atherosclerosis. As expected, the PdH‐Te nanozyme shows outstanding multiple antioxidant enzyme activities and sustained hydrogen release properties. Benefiting from decreased ROS levels by enzyme catalysis, PdH‐Te nanozyme significantly suppresses the pro‐inflammatory cytokines for atherosclerosis treatment. Taken together, the presented results demonstrate that inhibition of inflammation based on PdH‐Te nanozyme can effectively treat atherosclerosis, identifying an attractive strategy against cardiovascular diseases.
Funder
National Natural Science Foundation of China
Shanxi Scholarship Council of China
Subject
Condensed Matter Physics,General Materials Science,General Chemistry
Cited by
1 articles.
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